N-acetyltransferase ESCO1; CTF7 homolog 1; establishment factor-like protein 1; EFO1p; hEFO1; establishment of cohesion 1 homolog 1; ECO1 homolog 1; ESO1 homolog 1 (ESCO1, EFO1, KIAA1911)

Function

• acetyltransferase
• sister chromatid cohesion
• coupling of cohesion & DNA replication
  • sister chromatid pairing
• may function during S phase
• phosphorylated during mitosis
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• N-terminal region associates with chromosomes, thus the Zn finger is not needed for DNA association
• belongs to the acetyltransferase family, GCN5 subfamily

Compartment

• nucleus, nuclear at interphase
• associated with chromosomes during mitosis

Alternative splicing

named isoforms=3

Expression

• widely expressed
• expressed in heart, brain, liver, placenta, lung, kidney, pancreas, muscle
• highly expressed in muscle

Notes

• uncertain whether Met-1 or Met-2 is the initiator

More general terms

• acetyltransferase
• zinc finger protein
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=114799
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:114799
• OMIM: https://mirror.omim.org/entry/609674
• UniProt: http://www.uniprot.org/uniprot/Q5FWF5.html