cAMP-regulated phosphoprotein 21; ARPP-21; thymocyte cAMP-regulated phosphoprotein (ARPP21, TARPP)
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Function
- substrate for cAMP-dependent kinase
- isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons
- phosphorylation at Ser-56 favors interaction with CALM1
- isoform 1 is methylated by CARM1 in immature thymocytes
- interacts with CALM1 (putative)
Structure
contains 1 R3H domain
Compartment
Alternative splicing
named isoforms=6
Expression
- isoform 2 is expressed in brain
- isoform 1 is present in immature thymocytes (at protein level)
More general terms
References
- ↑ Hemmings HC & Greengard P ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Purification and characterization of the protein from bovine caudate nucleus. J Neurosci 9:851 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2538584
- ↑ Ouimet CC et al ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Immunocytochemical localization in rat brain. J Neruosci 9:865 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2538585
- ↑ Williams KR et al ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Amino acid sequence of ARPP-21B from bovine caudate nucleus. J Neurosci 9:3631 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2552036
- ↑ Kurihara T et al ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Molecular cloning and nucleotide sequence. J Neurosci 9:3638 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2552037
- ↑ UniProt http://www.uniprot.org/uniprot/Q9UBL0.html