DNA polymerase lambda (DNA polymerase kappa, DNA polymerase beta-2, POLL)

Function

• repair polymerase
• involved in base excision repair
• responsible for repair of lesions that give rise to apurinic apyrimidinic (AP) sites in DNA
• has both DNA polymerase & terminal transferase activities
• has a 5'-deoxyribose-5-phosphate lyase activity
• binds PCNA
• phosphorylated upon DNA damage, probably by ATM or ATR

Cofactor: Mn+2

Structure

• belongs to the DNA polymerase type-X family
• contains 1 BRCT domain

Compartment

nucleus

Expression

• expressed in a number of tissues
• abundant in testis

More general terms

• DNA polymerase
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2734
• OMIM: https://mirror.omim.org/entry/606343
• UniProt: http://www.uniprot.org/uniprot/Q9UGP5.html