Na+/K+ ATPase-alpha 1 (Na+ pump subunit alpha-1, Na+/K+ ATPase alpha-1 subunit, ATP1A1)

Function

• catalytic component of the active enzyme, which catalyzes hydrolysis of ATP coupled with the exchange of Na+ & K+ ions across the plasma membrane
• action creates the electrochemical gradient of Na+ & K+ ions, providing the energy for active transport of various nutrients
• phosphorylation on Tyr-10 modulates pumping activity

ATP + H2O + Na+(in) + K+(out)
            <-->
ADP + phosphate + Na+(out) + K+(in)

Structure

-belongs to the cation transport ATPase (P-type) family, type IIC subfamily

Compartment

membrane, melanosome

Alternative splicing

named isoforms=2

Expression

• predominant form in kidney
• expressed in most tissues

Genetics

Gene locus: 1p21

Notes

• produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• Na+/K+ ATPase-alpha
• transmembrane 10 protein
• phosphoprotein

Additional terms

• Na+/K+ ATPase

Database

• UniProt: http://www.uniprot.org/uniprot/P05023.html
• OMIM: https://mirror.omim.org/entry/182310
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=476