Na+/K+ ATPase

Function

• catalytic component of the active enzyme, which catalyzes hydrolysis of ATP coupled with the exchange of Na+ & K+ ions across the plasma membrane
• transports 3 Na+ out for 2 K+ in
• action creates the electrochemical gradient of Na+ & K+ ions, providing the energy for active transport of various nutrients

ATP + H2O + Na+(in) + K+(out) <--> ADP + phosphate + Na+(out) + K+(in)

Structure

• composed of three subunits: alpha (catalytic), beta & gamma

More general terms

• E1-E2 ATPase or P-type ATPase
• plasma membrane protein
• multisubunit protein
• electrogenic transporter

Database

• OMIM: https://mirror.omim.org/entry/182310