rhodopsin kinase ( RK, G protein-coupled receptor kinase 1, GRK1, RHOK)
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Function
- phosphorylates rhodopsin thereby initiating its deactivation
- autophosphorylated (putative)
- farnesylation is required for full activity (putative)
ATP + [rhodopsin] <--> ADP + [rhodopsin]phosphate
Structure
- belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family. GPRK subfamily
- related to beta adrenergic receptor kinase (BARK)
- contains 1 AGC-kinase C-terminal domain
- contains 1 protein kinase domain
- contains 1 RGS domain
Compartment
membrane; lipid-anchor
Expression
Retina & pineal gland (putative)
Pathology
- defects in GRK1 are the cause of Oguchi disease 2
More general terms
References
- ↑ Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ. beta-Arrestin: a protein that regulates beta-adrenergic receptor function. Science. 1990 Jun 22;248(4962):1547-50. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2163110
- ↑ Kemp BE, Pearson RB. Protein kinase recognition sequence motifs. Trends Biochem Sci. 1990 Sep;15(9):342-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2238044
- ↑ Pawson T Protein modules and signalling networks Nature 373:573 1995 (CaaX) PMID: https://www.ncbi.nlm.nih.gov/pubmed/7531822
- ↑ Mutations of the RHOK gene Note: Retina International's Scientific newsletter http://www.retina-international.com/sci-news/rkmut.htm
- ↑ UniProt http://www.uniprot.org/uniprot/Q15835.html