Rhodopsin; opsin-2 (RHO OPN2)

Function

• photoreceptor required for image-forming vision at low light intensity
• required for photoreceptor cell viability after birth
• light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation & release of all-trans retinal
• absorption (max)=495 nm
• phosphorylated on some or all of Ser & Thr in the C-terminal region
• phosphorylation lead to deactivation
• linked to transducin

Structure

• belongs to the G-protein coupled receptor 1 family opsin subfamily

Compartment

membrane

Expression

• rod shaped photoreceptor cells which mediate vision in dim light

Pathology

• defects in RHO are the cause of
  • retinitis pigmentosa type 4
  • retinitis pigmentosa autosomal recessive
  • congenital stationary night blindness 1 autosomal dominant

More general terms

• G-protein coupled receptor; serpentine receptor
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6010
• OMIM: https://mirror.omim.org/entry/180380
• OMIM: https://mirror.omim.org/entry/268000
• OMIM: https://mirror.omim.org/entry/610445
• UniProt: http://www.uniprot.org/uniprot/P08100.html