RB-associated KRAB zinc finger protein (RB-associated KRAB repressor, hRBaK, zinc finger protein 769, RBAK, ZNF769)

Function

• may repress E2F-dependent transcription
• may promote AR-dependent transcription
• interacts with AR & RB1
• may also interact with other nuclear hormone receptors such as NR3C1/GR

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 16 C2H2-type Zn+2 fingers
• contains 1 KRAB domain

Compartment

nucleus

Expression

• expressed in bone, brain, heart, kidney, liver, lung, pancreas & placenta

More general terms

• nuclear protein
• zinc finger protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5778
• UniProt: http://www.uniprot.org/uniprot/Q9NYW8.html