zinc finger protein 589 (stem cell Zn+2 finger protein 1, ZNF589, SZF1)

Function

• may play a role in hematopoietic stem/progenitor cell differentiation
• may play a role as a DNA binding-dependent transcriptional repressor
• interacts with TRIM28

Structure

• KRAB domain mediates interaction with TRIM28
• belongs to the krueppel C2H2-type zinc-finger protein family
• contains 4 C2H2-type zinc fingers
• contains 1 KRAB domain

Compartment

nucleus (putative)

Alternative splicing

named isoforms=3

Expression

• isoform 2 is widely expressed.
• isoform 3 is only expressed in CD34+ cells

More general terms

• nuclear protein
• C2H2 type zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q86UQ0.html