RPA-interacting protein (hRIP) (RPAIN RIP)

Function

• mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta
• isoform 2 is sumoylated & mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism
• interacts with the RPA1 subunit of RPA complex
• sumoylation is required for localization in nuclear PML body & transport of RPA complex in PML body
• upon UV irradiation & during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage
• sumoylation takes place at different Lys residues

Structure

contains 1 RIP-type zinc finger

Compartment

• isoform 1: cytoplasm, nucleus
• isoform 2: nucleus, only nuclear, localizes to PML body

Alternative splicing

named isoforms=7

Expression

• widely expressed
• expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus & spleen

More general terms

• zinc finger protein
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q86UA6.html