Speedy protein A (Speedy-1, Spy1, rapid inducer of G2/M progression in oocytes A, RINGO A, hSpy/Ringo A, SPDYA, SPDY1, SPY1)
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Function
- regulates the G1/S phase transition of the cell cycle by binding & activating CDC2, CDK2 & CDKN1B/KIP1
- can activate CDK2 without promoting CDK2 phosphorylation
- mediates cell survival during the DNA damage process through activation of CDK2
- interacts with CDC2, CDK2 & CDKN1B/KIP1
- found in a complex with both CDK2 & CDKN1B/KIP1
Structure
- belongs to the Speedy/Ringo family
- C-terminus is required for CDK2-activation, but not CDK2-binding
Compartment
Alternative splicing
named isoforms=2
Expression
- highly expressed in testis
- expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea & uterus
- expressed at a slightly higher level in adrenal gland, cerebellum, small intestine, lung, prostate & trachea
- expression is cell cycle-dependent, being restricted to cells in G1/S phase