signal-transducing adaptor protein 2; STAP-2; breast tumor kinase substrate; BRK substrate (STAP2, BKS)

Function

• substrate of protein kinase PTK6
• may play a regulatory role in the acute-phase response in systemic inflammation
• may modulate STAT3 activity
• interacts with PTK6 & CSF1R
• phosphorylated on Tyr
  • Tyr-250 facilitates interaction with kinases
  • Tyr-22 & Tyr-322 phosphorylated by SRC

Structure

• contains 1 PH domain
• contains 1 SH2 domain

Compartment

cytoplasm

Expression

widely expressed

More general terms

• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55620
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55620
• OMIM: https://mirror.omim.org/entry/607881
• UniProt: http://www.uniprot.org/uniprot/Q9UGK3.html