nuclear LIM interactor-interacting factor (NLI-interacting factor)
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Function
- preferentially catalyzes dephosphorylation of Ser-5 within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase 2 subunit POLR2A
- negatively regulates RNA polymerase 2 transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (putative)
- recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells
- interacts with REST
Cofactor: binds 1 Mg+2 per monomer (putative)
Structure
Compartment
Expression
- expression is restricted to non-neuronal tissues
More general terms
More specific terms
- carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; nuclear LIM interactor-interacting factor 3; NLI-IF; NLI-interacting factor 3; small C-terminal domain phosphatase 1; SCP1; small CTD phosphatase 1 (CTDSP1, NIF3, NLIIF, SCP1)
- carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2; nuclear LIM interactor-interacting factor 2; NLI-interacting factor 2; protein OS-4; small C-terminal domain phosphatase 2; small CTD phosphatase 2; SCP2 (CTDSP2, NIF2, OS4, S...
- CTD small phosphatase-like protein; CTDSP-like; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; NIF-like protein; nuclear LIM interactor-interacting factor 1; NLI-interacting factor 1; protein YA22; hYA22; RBSP3; small C-te...