CTD small phosphatase-like protein; CTDSP-like; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; NIF-like protein; nuclear LIM interactor-interacting factor 1; NLI-interacting factor 1; protein YA22; hYA22; RBSP3; small C-terminal domain phosphatase 3; SCP3; small CTD phosphatase 3 (CTDSPL, C3orf8, NIF1, NIFL, SCP3, YA22)

Function

• preferentially catalyzes dephosphorylation of Ser-5 within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase 2 subunit POLR2A
• negatively regulates RNA polymerase 2 transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (putative)
• recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells
• interacts with REST

Cofactor: binds 1 Mg+2 per monomer (putative)

Structure

• monomer
• contains 1 FCP1 homology domain

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Expression

• expression is restricted to non-neuronal tissues

More general terms

• NLI-interacting factor
• phosphoprotein

Additional terms

• LIM domain
• LIM domain protein kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10217
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10217
• OMIM: https://mirror.omim.org/entry/608592
• UniProt: http://www.uniprot.org/uniprot/O15194.html