nucleolar protein 3; apoptosis repressor with CARD; muscle-enriched cytoplasmic protein; Myp; nucleolar protein of 30 kD; Nop30 (NOL3, ARC, NOP)

Function

• interacts with TFPT (putative)
• isoform 1
  • may be involved in RNA splicing
  • oligomerizes & binds to SFRS9/SRp30C
  • interacts with NPM1
• isoform 2
  • may inhibit apoptosis
  • binds CASP2/caspase-2 & CASP8/caspase-8
  • inhibits caspase-8 activity

Structure

contains 1 CARD domain

Compartment

• isoform 1: nucleus, nucleolus
• isoform 2: cytoplasm

Alternative splicing

named isoforms=2

Expression

• highly expressed in heart & skeletal muscle
• expressed at low levels in placenta, liver, kidney & pancreas

More general terms

• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8996
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8996
• OMIM: https://mirror.omim.org/entry/605235
• UniProt: http://www.uniprot.org/uniprot/O60936.html