dual specificity protein phosphatase CDC14B; CDC14 cell division cycle 14 homolog B (CDC14B)

Function

• dual-specificity phosphatase involved in DNA damage response
• essential regulator of the G2 DNA damage checkpoint:
  • following DNA damage, translocates from the nucleolus to the nucleoplasm & dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C)
  • dephosphorylation of FZR1/CDH1 activates the cyclosome, leading to ubiquitination of PLK1, preventing entry into mitosis
• preferentially dephosphorylates proteins modified by proline-directed kinases
• interacts with FZR1/CDH1

Structure

• composed of two structurally equivalent A & B domains that adopt a dual specificity protein phosphatase (DSP) fold
• belongs to the protein-tyrosine phosphatase family non-receptor class CDC14 subfamily

Compartment

• nucleus, nucleolus, nucleoplasm
• following DNA damage, translocates from the nucleolus to the nucleoplasm & interacts with FZR1/CDH1
• nucleolus during interphase

Alternative splicing

named isoforms=4

More general terms

• dual specificity phosphatase
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8555
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8555
• OMIM: https://mirror.omim.org/entry/603505
• UniProt: http://www.uniprot.org/uniprot/O60729.html