endothelial cell-specific molecule 1 (ESM-1 secretory protein, ESM-1, ESM1)

Function

• role in lung endothelial cell-leukocyte interactions

Structure

• monomer
• may contain intrachain disulfide bonds.
• contains 1 IGFBP domain

Compartment

secreted

Expression

• expressed in lung, on vascular capillary network within alveolar walls > kidney
• induced by TNF-alpha & IL-1 beta, but not IL-4

More general terms

• secreted protein

Database

• OMIM: https://mirror.omim.org/entry/601521
• UniProt: http://www.uniprot.org/uniprot/Q9NQ30.html