acrosin-binding protein (acrosin-binding protein sp32, cancer testis antigen OY-TES-1, ACRBP)

Function

• role in packaging & condensation of acrosin zymogen in acrosomal matrix via its association with acrosin (proacrosin)
• binds acrosin (proacrosin)
• phosphorylated on Tyr residues in capacitated sperm

Structure

• N-terminus is blocked

Compartment

• secreted, acrosome
• colocalizes with acrosin (proacrosin) in acrosome of sperm

Expression

restricted to testis in normal tissue

Pathology

• expressed in a wide spectrum of cancers, including bladder cancer, breast cancer, liver cancer, lung cancer & colon cancer

More general terms

• secreted protein

Additional terms

• acrosin ([contains: acrosin light chain; Acrosin heavy chain], ACR, ACRS)

Database

• OMIM: https://mirror.omim.org/entry/608352
• UniProt: http://www.uniprot.org/uniprot/Q8NEB7.html