acrosin ([contains: acrosin light chain; Acrosin heavy chain], ACR, ACRS)

Function

• major protease of mammalian spermatozoa
• serine protease of trypsin-like cleavage specificity
• synthesized in a zymogen form, proacrosin & stored in the acrosome
• preferential cleavage: Arg-|-Xaa, Lys-|-Xaa

Structure

• heavy chain (catalytic) & a light chain linked by two disulfide bonds
• belongs to the peptidase S1 family
• contains 1 peptidase S1 domain

Laboratory

• acrosin in spermatozoa

More general terms

• serine protease trypsin family

Database

• UniProt: http://www.uniprot.org/uniprot/P10323.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:49;
• OMIM: https://mirror.omim.org/entry/102480
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=49