tuberoinfundibular peptide of 39 residues (TIP39, TIPF39)

Function

• role as selective agonist of PTHR2 with adenyl cyclase activation & intracellular Ca+2 influx
• induces protein kinase C beta activation, recruitment of beta-arrestin & PTH2R internalization
• inhibits cell proliferation via PTHR2 activation (putative)
• neuropeptide, activate nociceptors & nociceptive circuits (putative)
• role in spermatogenesis (putative)

Structure

• belongs to the parathyroid hormone family

Compartment

secreted

Expression

• expressed in fetal & adult brain, cerebellum, trachea > spinal cord, fetal liver, kidney, heart

More general terms

• secreted protein

Database

• OMIM: https://mirror.omim.org/entry/608386
• UniProt: http://www.uniprot.org/uniprot/Q96A98.html