nociceptive pain

Etiology

• somatic: tissue injury: bones, soft tissue, joints, muscle
• visceral: renal colic, constipation

Pathology

• pain transmission (nociception)
  • usually relating to a receptive neuron (nociceptin receptor) for painful sensations

Clinical manifestations

• somatic:
  • localized to site of tissue injury
  • dull, aching or throbbing pain
• visceral:
  • diffuse, poorly localized, referred to other sites
  • intermittent, paroxysmal
  • dull, colicky, squeezing, deep, cramping
  • often with nausea, vomiting, diaphoresis

Management

• somatic
  • physical therapy
  • cognitive behavioral therapy
  • acetaminophen, NSAIDs, opiates
• visceral
  • treatment of underlying cause
  • physical therapy
  • cognitive behavioral therapy
  • acetaminophen, opiates

More general terms

• pain [odyn-]

Additional terms

• nociceptin ([Contains: Neuropeptide 1; Nociceptin (Orphanin FQ) (PPNOC); Neuropeptide 2], PNOC, OFQ)
• nociceptin receptor; orphanin FQ receptor; kappa-type 3 opioid receptor; KOR-3 (OPRL1 OOR ORL1)
• nociception
• nociceptor