nociceptin ([Contains: Neuropeptide 1; Nociceptin (Orphanin FQ) (PPNOC); Neuropeptide 2], PNOC, OFQ)

Function

• ligand of the opioid receptor-like receptor (OPRL1)
• putative transmitter in the brain, modulating nociceptive & locomotor behavior
• role in neuronal differentiation & development (putative)
• specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin

Structure

• N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding &/or processing

Compartment

secreted

Expression

expressed predominantly in brain & spinal cord

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/601459
• UniProt: http://www.uniprot.org/uniprot/Q13519.html