nociceptin receptor; orphanin FQ receptor; kappa-type 3 opioid receptor; KOR-3 (OPRL1 OOR ORL1)

Function

• receptor for the neuropeptide nociceptin/orphanin FQ
• potential role in modulating a number of brain functions, including instinctive behaviors & emotions
• activity is mediated by Gi protein (inhibition of adenylyl cyclase)

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane; multi-pass membrane protein

Alternative splicing

named isoforms=2

Expression

induced by phytohemagglutinin (PHA)

More general terms

• endorphin receptor or opioid receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4987
• OMIM: https://mirror.omim.org/entry/602548
• UniProt: http://www.uniprot.org/uniprot/P41146.html