enteropeptidase; enterokinase; serine protease 7; transmembrane protease serine 15 (TMPRSS15, ENTK, PRSS7)

Function

• responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin & carboxypeptidase A)
• catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, & proelastases
• activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond
• the chains are derived from a single precursor that is cleaved by a trypsin-like protease
• heterodimer of a catalytic (light) chain & a multidomain (heavy) chain linked by a disulfide bond

Structure

• belongs to the peptidase S1 family
• contains 2 CUB domains
• contains 2 LDL-receptor class A domains
• contains 1 MAM domain
• contains 1 peptidase S1 domain
• contains 1 SEA domain
• contains 1 SRCR domain

Compartment

• membrane; single-pass type 2 membrane protein (probable)

Expression

intestinal brush border

Pathology

• defects in TMPRSS15 are a cause of enterokinase deficiency

More general terms

• serine protease
• secreted protein
• myristoylated protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5651
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5651
• OMIM: https://mirror.omim.org/entry/226200
• OMIM: https://mirror.omim.org/entry/606635
• UniProt: http://www.uniprot.org/uniprot/P98073.html