kallikrein-11; hK11; hippostasin; serine protease 20; trypsin-like protease; contains: kallikrein-11 inactive chain 1 & kallikrein-11 inactive chain 2 (KLK11, PRSS20, TLSP, UNQ649/PRO1279)

Function

• possible multifunctional protease
• efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, & weakly cleaves other substrates for kallikrein & trypsin
• cleaves synthetic peptides after Arg but not Lys
• about 40% of KLK11 is inactivated by internal cleavage after Arg-188 (may be effected by plasminogen)

Structure

• belongs to the peptidase S1 family, kallikrein subfamily
• contains 1 peptidase S1 domain

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

• expressed in brain, skin & prostate
• isoform 1 is expressed preferentially in brain
• isoform 2 is expressed in prostate
  • present in seminal plasma at concentrations ranging from 2 -37 ug/mL (at protein level)

More general terms

• kallikrein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11012
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11012
• OMIM: https://mirror.omim.org/entry/604434
• UniProt: http://www.uniprot.org/uniprot/Q9UBX7.html