mucin-16 (ovarian carcinoma antigen CA125, ovarian cancer related tumor marker CA125, CA-125, MUC16, CA125)

Function

• provides a protective, lubricating barrier against particles & infectious agents at mucosal surfaces
• binds to MSLN
• binding to MSLN mediates heterotypic cell adhesion

Structure

• heavily N- & O-glycosylated
• contains 2 ANK repeats
• contains 14 LRR repeats (leucine-rich repeats)
• contains 56 SEA domains

Compartment

• cell membrane, secreted protein
• may be secreted following the phosphorylation of intracellular C-terminus which induces proteolytic cleavage & liberation of extracellular domain

Expression

• expressed in corneal & conjunctival epithelia

Pathology

• heterotypic cell adhesion may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN
• overexpressed in ovarian carcinomas & ovarian low malignant potential (LMP) tumors as compared to expression in normal ovarian tissue & ovarian adenomas

Polymorphism

number of repeats is highly polymorphic

Laboratory

• cancer antigen CA125 in tissue
• cancer antigen CA125 in body fluid
  • cancer antigen CA125 in serum

More general terms

• mucin
• secreted protein

Additional terms

• cancer antigen CA 125 in serum

Database

• OMIM: https://mirror.omim.org/entry/606154
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=94025
• UniProt: http://www.uniprot.org/uniprot/Q8WXI7.html