mesothelin; CAK1 antigen; pre-pro-megakaryocyte-potentiating factor; contains: megakaryocyte-potentiating factor; MPF; mesothelin, cleaved form (MSLN, MPF)

Function

• membrane-anchored forms may play a role in cellular adhesion
• megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro
• proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), & the cleaved form of mesothelin
• both MPF & the cleaved form of mesothelin are N-glycosylated
• interacts with MUC16

Structure

• belongs to the mesothelin family

Compartment

• cell membrane; lipid-anchor, GPI-anchor Golgi apparatus
• megakaryocyte-potentiating factor: secreted
• isoform 3: secreted

Alternative splicing

• named isoforms=4; minor form, major form

Expression

• expressed in lung
• expressed at low levels in heart, placenta & kidney
• expressed in mesothelial cells
• highly expressed in mesotheliomas, ovarian cancers, & some squamous cell carcinomas (at protein level)

Pathology

• antibodies against MSLN are detected in patients with mesothelioma & ovarian cancer
• soluble form found in the sera from patients with ovarian carcinoma

More general terms

• glypiated protein
• protein precursor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10232
• OMIM: https://mirror.omim.org/entry/601051
• UniProt: http://www.uniprot.org/uniprot/Q13421.html