ciliary neurotrophic factor receptor alpha; CNTFR alpha (CNTFR)
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Function
- binds to CNTF
- alpha chain provides receptor specificity
Structure
- WSXWS motif appears to be necessary for proper protein folding & thus efficient intracellular transport & cell-surface receptor binding
- belongs to the type I cytokine receptor family, type 3 subfamily
- contains 2 fibronectin F3 modules
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
Compartment
cell membrane; lipid-anchor, GPI-anchor
Expression
nervous system & skeletal muscle
More general terms
Component of
References
- ↑ Miyajima A, Hara T, Kitamura T. Common subunits of cytokine receptors and the functional redundancy of cytokines. Trends Biochem Sci. 1992 Oct;17(10):378-82. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1455505
- ↑ Taga T and Kishimoto T Cytokine receptors and signal transduction. FASEB J 6:3387 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1334470
- ↑ UniProt http://www.uniprot.org/uniprot/P26992.html