DNA fragmentation factor subunit beta; DNA fragmentation factor 40 kD subunit; DFF-40; caspase-activated deoxyribonuclease; Caspase-activated Dnase; CAD; caspase-activated nuclease; CPAN (DFFB, CAD, DFF2, DFF40)

Function

• active component of DNA fragmentation factor
• nuclease that induces DNA fragmentation & chromatin condensation during apoptosis
• degrades naked DNA & induces apoptotic morphology
• inhibited by DFFA (DFF45)
• heterodimer of DFFA & DFFB

Structure

• contains 1 CIDE-N domain

Compartment

• cytoplasm, nucleus

Alternative splicing

• named isoforms=4; alpha, beta, gamma, delta
• some isoforms may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• protein subunit
• deoxyribonuclease (DNase)

Component of

• DNA fragmentation factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1677
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1677
• OMIM: https://mirror.omim.org/entry/601883
• UniProt: http://www.uniprot.org/uniprot/O76075.html