DNA fragmentation factor subunit alpha; DNA fragmentation factor 45 kD subunit; DFF-45; inhibitor of CAD; ICAD (DFFA, DFF1, DFF45, H13)

Function

• inhibitor of the caspase-activated Dnase (DFFB)
• caspase-3 cleaves DFF45 at 2 sites to generate an active form
• phosphorylated upon DNA damage, probably by ATM or ATR
• heterodimer of DFFA & DFFB

Structure

• contains 1 CIDE-N domain

Compartment

• cytoplasm

Alternative splicing

• named isoforms=2; DFF45, DFF35

More general terms

• protein subunit
• phosphoprotein

Component of

• DNA fragmentation factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1676
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1676
• Kegg: http://www.genome.jp/dbget-bin/www_bget?
• OMIM: https://mirror.omim.org/entry/601882
• UniProt: http://www.uniprot.org/uniprot/O00273.html