NADPH oxidase 5 (NOX5)

Function

• Ca+2-dependent NADPH oxidase subunit
• generates superoxide
• Ca+2-dependent proton channel
  • activate by Ca+2
• may regulate redox-dependent processes in lymphocytes & spermatozoa
• role in cell growth & apoptosis
• down-regulated by TGFB1

Cofactor: FAD, Mg+2

Inhibition:

• inhibited by diphenylene iodonium

Kinetic parameters:

• KM=1.06 uM for Ca+2

Compartment

membrane

Alternative splicing

named isoforms=5

Expression

• expressed in pachytene spermatocytes of testis, lymphocyte-rich areas of spleen & lymph nodes > ovary, placenta, pancreas, cardiac fibroblasts, B-cells, prostate malignant cells, isoform 3 expressed in spleen, isoform 4 expressed in testis
• expressed in fetal tissues

Pathology

• associated with increased proliferative capacity & diminished apoptosis
• implicated in transformation of Barrett esophagus, melanoma, prostate cancer

More general terms

• protein subunit
• transmembrane 7c protein

Component of

• NADPH oxidase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7940
• OMIM: https://mirror.omim.org/entry/606572
• UniProt: http://www.uniprot.org/uniprot/Q96PH1.html