Fanconi anemia-associated protein of 100 kD (FAAP100, C17orf70)

Function

• role in Fanconi anemia-associated DNA damage response network
• regulates FANCD2 monoubiquitylation & the stability of the FA core complex
• induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed
• component of the multisubunit FA complex
• forms subcomplex with FANCB & FANCL

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• other protein

Additional terms

• Fanconi anemia

Component of

• Fanconi anemia complementation group complex (FA complex)

Database

• UniProt: http://www.uniprot.org/uniprot/Q0VG06.html