protein VPRBP (HIV-1 Vpr-binding protein, VprBP, Vpr-interacting protein, DDB1- & CUL4-associated factor 1, VPRBP, DCAF1, KIAA0800, RIP)

Function

• ubiquitin conjugation, 3rd step
• may act as a receptor for CUL4-DDB1 ubiquitin ligase complex
• interacts with DDB1, suggesting that it may participate to some RBX1-CUL4-DDB2 ubiquitin ligase complex

Structure

• belongs to the VPRBP family
• contains 1 LisH domain
• although not canonical, the WD repeat-like region is related to WD repeats

Compartment

cytoplasm

Alternative splicing

named isoforms=3

Expression

ubiquitously expressed

Pathology

• in case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr, possibly leading to hijack the RBX1-CUL4-DDB2 & arrest the cell cycle in G2 phase

forms ternary complex with HIV-1 Vpr & DDB1

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y4B6.html