B-cell scaffold protein with ankyrin repeats (BANK1)

Function

• role in B-cell receptor (BCR) induced Ca+2 mobilization from intracellular stores
• promotes Lyn-mediated phosphorylation of IP3 receptor 1 & IP3 receptor 2

interacts with LYN, ITPR1 and ITPR2

phosphorylated on Tyr upon BCR activation

Structure

contains 2 ANK repeats

Alternative splicing

named isoforms=3

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NDB2.html