proteasome maturation protein (proteassemblin, protein UMP1 homolog, hUMP1, voltage-gated K channel beta subunit 4.1, POMP, C13orf12, UMP1, HSPC014, HSPC036, PNAS-110)

Function

• molecular chaperone essential for assembly of standard proteasomes & immunoproteasomes
• degraded after completion of proteasome maturation
• constituent of preproteasomes, but not of mature 20S proteasomes
• within the preproteasome, may directly interact with PSMB1/beta6, PSMB4/beta7, PSMB5/beta5, PSMB6/beta1 & PSMB9/ beta1i
• interaction with PSMB8/beta5i inconsistent
• forms tetramers
• although named voltage-gated K+channel beta subunit 4.1, no evidence that it plays a role in ion transport.

Compartment

• cytoplasm, nucleus

Expression

• induced by interferon gamma
• belongs to the POMP/UMP1 family

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y244.html