LMP-2/ring-12 protein (proteasome subunit beta type-9, proteasome chain 7, macropain chain 7, multicatalytic endopeptidase complex chain 7, RING12 protein, low molecular mass protein 2, PSMB9, LMP2, RING12)

Function

• component of the 20S proteasome which is a component of the 26S proteasome
• PSMB9 is involved in antigen processing to generate MHC class 1 binding peptides
• PSMB9 displaces the equivalent houskeeping subunit PSMB6
• a model for self-activation in which residue Thr-21 serves as nucleophile & Lys-53 as proton donor/acceptor has been proposed

Structure

belongs to the peptidase T1B family

Compartment

cytoplasm (putative), nucleus

Alternative splicing

named isoforms=2

Expression

induced by interferon gamma

Genetics

encoded in the MHC class 2 region

Notes

A model for self-activation in which residue Thr-21 serves as nucleophile & Lys-53 as proton donor/acceptor has been proposed. subunit processing of mammalian beta-subunits proceeds via a novel ordered two-step mechanism involving autocatalysis

More general terms

• macropain-beta subunit

Component of

• 20S proteasome

Database

• UniProt: http://www.uniprot.org/uniprot/P28065.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5698
• OMIM: https://mirror.omim.org/entry/177045