LMP-7/ring-10 protein (proteasome subunit beta type-8, macropain-C13 subunit, proteasome component C13, multicatalytic endopeptidase complex subunit C13, PSMB8, LMP7, RING10, Y2)

Function

• component of the 20S proteasome which is a component of the 26S proteasome
• PSMB8 is involved in antigen processing to generate MHC class 1 binding peptides
• PSMB8 is part of the immunoproteasome where it displaces the equivalent housekeeping subunit PSMB5
• directly interacts with POMP

Structure

belongs to the peptidase T1B family

Compartment

cytoplasm (putative), nucleus

Alternative splicing

• named isoforms=2
• additional isoforms seem to exist

More general terms

• macropain-beta subunit

Component of

• 20S proteasome

Database

• UniProt: http://www.uniprot.org/uniprot/P28062.html
• OMIM: https://mirror.omim.org/entry/177046