nebulin-related anchoring protein (N-RAP, NRAP)

Function

• anchoring terminal actin filaments in the myofibril to membrane
• transmitting tension from myofibrils to extracellular matrix
• interacts with actin, alpha-actinin, KBTBD10, TLN1, VCL

Structure

• contains 1 LIM zinc-binding domain contains 44 nebulin repeats

Compartment

• localized at myotendinous junction in skeletal muscle & at the intercalated disk in cardiac muscle

Alternative splicing

named isoforms=4

Expression

• expressed in cardiac, skeletal muscle

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/602873
• UniProt: http://www.uniprot.org/uniprot/Q86VF7.html