kelch-like protein 41; kel-like protein 23; kelch repeat & BTB domain-containing protein 10; kelch-related protein 1; sarcosin (KLHL41, KBTBD10, KRP1)

Function

• role in skeletal muscle development & differentiation
• regulates proliferation & differentiation of myoblasts
• role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils
• required for pseudopod elongation in transformed cells
• substrate-specific adapter of BCR E3 ubiquitin ligase complex that contains CUL3, RBX1 & KBTBD10
• protein modification; protein ubiquitination
• ubiquitinated & probably targeted for proteasome- independent degradation
• quinone-induced oxidative stress increases its ubiquitination
• interacts with NRAP (putative)
• interacts with LASP1

Structure

• contains 1 BACK (BTB/kelch associated) domain
• contains 1 BTB/POZ domain
• contains 5 kelch repeats

Compartment

• cytoplasm. cytoplasm, cytoskeleton
• cell projection, pseudopodium, ruffle
• sarcomere, M line (putative)
• predominantly cytoplasmic but can co-localize with F-actin at membrane ruffle-like structures at the tips of transformation-specific pseudopodia

Alternative splicing

named isoforms=2; long, short

Expression

sarcomeric muscle

More general terms

• Kelch repeat & BTB domain containing protein
• kelch-like protein
• cytoskeletal protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10324
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10324
• OMIM: https://mirror.omim.org/entry/607701
• UniProt: http://www.uniprot.org/uniprot/O60662.html