LIM & SH3 domain protein 1; LASP-1; metastatic lymph node gene 50 protein; MLN 50 (LASP1, MLN50)

Function

• role in regulation of dynamic actin-based, cytoskeletal activities
• agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, in parietal cells & in certain other F-actin-rich secretory epithelial cell types
• interacts with F-actin (putative)

Structure

• contains 1 LIM Zn+2-binding domain
• contains 2 nebulin repeats
• contains 1 SH3 domain

Compartment

• cytoplasm, cell cortex, cytoskeleton (putative)
• associated with the F-actin rich cortical cytoskeleton (putative)

Alternative splicing

named isoforms=2

More general terms

• cytoskeletal protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3927
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3927
• OMIM: https://mirror.omim.org/entry/602920
• UniProt: http://www.uniprot.org/uniprot/Q14847.html