suppressor of T-cell receptor signaling 2 (STS-2, Cbl-interacting protein 4, CLIP4, T-cell ubiquitin ligand, TULA, UBASH3A, STS2)

Function

• interferes with CBL-mediated down-regulation & degradation of receptor tyrosine kinases
• promotes accumulation of activated target receptors, including T-cell receptors, EGFR & PDGFRB on cell surface
• homodimer or homooligomer
• interacts with CBL
• component of complex containing CBL & activated EGFR
• interacts with ubiquitin & with mono-ubiquitinated proteins

Structure

• contains 1 SH3 domain
• contains 1 UBA domain

Compartment

cytoplasm, nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in tissues of the immune system, including spleen, peripheral blood leukocytes, thymus, bone marrow

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/605736
• UniProt: http://www.uniprot.org/uniprot/P57075.html