density-regulated protein; DRP; DRP1 protein; smooth muscle cell-associated protein 3; SMAP-3 (DENR, DRP1, H14)

Function

• role in translation of target mRNAs by scanning & recognition of the initiation codon
• role in translation initiation
  • promotes recruitment of aminoacetyled initiator tRNA to the P site of 40S ribosomes
  • can promote release of deacylated tRNA & mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits
• role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1
• interacts with MCTS1

Structure

• belongs to the DENR family,
• contains 1 SUI1 domain

Expression

• expressed highest amounts in skeletal muscle & cardiac muscle
• moderate expression in the brain, placenta, liver & pancreas
• weak expression in lung & kidney
• up-regulated with increasing cell-density by HNRNPD
• up-regulated in ovarian & breast cancer cells by ERBB2 overexpression
• not induced by TGFB1

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8562
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8562
• OMIM: https://mirror.omim.org/entry/604550
• UniProt: http://www.uniprot.org/uniprot/O43583.html