ATP-binding cassette, sub-family E (OABP), member 1 (RNase L inhibitor, ribonuclease 4 inhibitor, RNS4I, 2'-5' oligoadenylate-binding protein, HuHP68, ABCE1, RLI, OK/SW-cl40)

Function

• antagonizes RNase L endoribonuclease activity
• probably heterodimerizes with Rnase L
• regulation of mRNA turnover
• antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway

Structure

• belongs to the ABC transporter family, ABCE subfamily
• contains 2 4Fe-4S ferredoxin-type domains
• contains 2 ABC transporter domains (probably not functional)

Compartment

• cytoplasm
• mitochondria

Expression

• activated by encephalomyocarditis virus (EMCV) & HIV-1

Pathology

• localized to clusters of virus formation at plasma membrane
• associates with HIV-1 Vif & HIV-1, HIV-2 & SIV Gag proteins
• chaperone for post-translational events during HIV-1 capsid assembly (putative)

More general terms

• ATP-binding cassette sub-family E (ABC transporter-E, ABCE)

Database

• OMIM: https://mirror.omim.org/entry/601213
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6059
• UniProt: http://www.uniprot.org/uniprot/P61221.html