apoptosis facilitator Bcl-2-like protein 14; Bcl2-L-14; apoptosis regulator Bcl-G (BCL2L14, BCLG)

Function

• plays a role in apoptosis
• phosphorylated by MELK, leading to inhibit its pro-apoptotic function

Structure

belongs to the Bcl-2 family

Compartment

• isoform 1: cytoplasm; diffusely distributed throughout the cytoplasm
• isoform 2: endomembrane system; predominantly localized to cytosolic organelles

Alternative splicing

• named isoforms=3
• at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Expression

• isoform 1 is widely expressed
• isoform 2 is testis-specific

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79370
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79370
• OMIM: https://mirror.omim.org/entry/606126
• UniProt: http://www.uniprot.org/uniprot/Q9BZR8.html