maternal embryonic leucine zipper kinase; hMELK; protein kinase PK38; hPK38 (MELK, KIAA0175)

Function

• phosphorylates ZNF622; may contribute to its translocation to the nucleus
• may be involved in the inhibition of spliceosome assembly during mitosis
• autophosphorylated
• Thr-478 phosphorylation during mitosis promotes interaction with PPP1R8 (probable)
• interacts with ZNF622 & PPP1R8

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
• contains 1 KA1 (kinase-associated) domain
• contains 1 protein kinase domain

Compartment

cytoplasm (putative)

Expression

• expressed in placenta, kidney, thymus, testis, ovary & intestine

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9833
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9833
• OMIM: https://mirror.omim.org/entry/607025
• UniProt: http://www.uniprot.org/uniprot/Q14680.html