connector enhancer of kinase suppressor of ras 1; connector enhancer of KSR 1; CNK homolog protein 1; CNK1; hCNK1; connector enhancer of KSR-like (CNKSR1, CNK1)

Function

• adapter protein
• regulation of Ras signaling pathways
• phosphorylated on Tyr
• interacts with RHO, RALGDS

Structure

• belongs to the CNKSR family
• contains 1 CRIC domain
• contains 1 PDZ domain (DHR domain)
• contains 1 PH domain
• contains 1 SAM (sterile alpha motif) domain

Compartment

cytoplasmic & membrane-associated

Alternative splicing

named isoforms=2

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10256
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10256
• OMIM: https://mirror.omim.org/entry/603272
• UniProt: http://www.uniprot.org/uniprot/Q969H4.html