Teashirt homolog 2; ovarian cancer-related protein 10-2; OVC10-2; zinc finger protein 218 (TSHZ2, C20orf17, TSH2, ZNF218)

Function

• probable transcriptional regulator involved in developmental processes
• may act as a transcriptional repressor
• sumoylated
• interacts (via homeobox domain) with APBB1 (via 1st PID domain) (putative)

Structure

• belongs to the teashirt C2H2-type Zn+2-finger protein family
• contains 5 C2H2-type Zn+2 fingers
• contains 1 homeobox DNA-binding domain

Compartment

nucleus (probable)

Expression

• expressed in brain

Pathology

• strongly reduced in post-mortem elderly subjects with Alzheimer disease

More general terms

• nuclear protein
• C2H2 type zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7765
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=128553
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:128553
• UniProt: http://www.uniprot.org/uniprot/Q9NRE2.html