selenium-binding protein 1; 56 kD selenium-binding protein; SBP56; SP56 (SELENBP1 SBP)

Function

• selenium-binding protein
• may be involved in sensing of reactive xenobiotics in the cytoplasm
• may be involved in intra-Golgi protein transport
• phosphorylated (probable)
• interacts with USP33

Structure

• the N-terminus is blocked (putative)
• belongs to the selenium-binding protein family

Compartment

• nucleus, cytoplasm, cytosol, membrane
• peripheral membrane protein (putative)
• may associate with Golgi membrane
• may associate with the membrane of autophagosomes

Alternative splicing

named isoforms=2

Expression

• highly expressed in liver, lung, colon, prostate, kidney & pancreas
• expressed in brain, both in neurons & glia (at protein level)
• down-regulated in lung adenocarcinoma, colorectal carcinoma & ovarian cancer
• two-fold up-regulated in brain & blood from patients with schizophrenia
• expression down-regulated by androgen in prostate cancer cells

More general terms

• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8991
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8991
• OMIM: https://mirror.omim.org/entry/604188
• UniProt: http://www.uniprot.org/uniprot/Q13228.html