ubiquitin fusion degradation protein 1 homolog; UB fusion protein 1 (UFD1L)

Function

• component of ubiquitin-dependent proteolytic pathway that degrades ubiquitin fusion proteins
• the ternary complex containing UFD1L, VCP & NPLOC4 binds ubiquitinated proteins & is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome
• the NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis & is necessary for the formation of a closed nuclear envelope.
• may be involved in the development of some ectoderm-derived structures
• protein degradation; proteasomal ubiquitin-dependent pathway
• heterodimer with NPLOC4; heterodimer binds VCP & inhibits Golgi membrane fusion

Structure

belongs to the UFD1 family

Compartment

• nucleus (putative)
• cytoplasm

Alternative splicing

named isoforms=2

Expression

• found in adult heart, skeletal muscle & pancreas, & in fetal liver & kidney

More general terms

• nuclear protein
• phosphoprotein

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7353
• OMIM: https://mirror.omim.org/entry/601754
• UniProt: http://www.uniprot.org/uniprot/Q92890.html