NPLOC4-UFD1L-VCP complex

Function

• binds ubiquitinated proteins
• role in export of misfolded proteins from ER to cytoplasm, where they are degraded by the proteasome
• regulates spindle disassembly at the end of mitosis
• role in formation of a closed nuclear envelope
• ubiquitin fusion protein degradation (UFD) pathway

Structure

• consists of: ternary complex containing UFD1L, VCP & NPLOC4

More general terms

• molecular complex